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Nline submission ?Thorough peer review ?Inclusion in PubMed and all major indexing services ?Maximum visibility for your research Submit your manuscript at www.biomedcentral.com/submitQuadri et al. BMC Cancer (2017) 17:495 DOI 10.1186/s12885-017-3481-RESEARCH ARTICLEOpen AccessExpression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical out
Enhancer of the Kinase Suppressor of Ras-1), a regulator and binding partner of KSR1, is another scaffolding protein which is less understood. Its role in pancreatic cancer biology, or as a biomarker, remains to be explored. Current data suggests that CNKSR1 has multiple roles cancer biology, with some reports demonstrating that CNKSR1 interacts with tumor suppressors and othersdescribe its scaff
Patients for individualized clinical decision-making would fill an unmet clinical need. Activating somatic KRAS mutations are nearly omnipresent and a hallmark in the genetic make-up of pancreatic ductal adenocarcinoma (PDAC) [5]. While KRAS mutations themselves have been associated as prognostic markers, there is considerable and significant heterogeneity in the activation states of the downstre
Esults in an increased sensitivity to TGF-beta signaling. BMC Cancer. 2011;11:59. PubMed. 31. Imamichi Y, Waidmann O, Hein R, Eleftheriou P, Giehl K, Menke A. TGF betainduced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4. Biol Chem. 2005;386(3):225-236. PubMed. 32. Gauger KJ, Shimono A, Crisi GM, Schneider SS. Loss of SFRP
On by age, race, gender, grade, resection status, the TNM variables lymph node status (N0; No regional lymph node metastasis, N1; Regional lymph node metastasis, and NX;Quadri et al. BMC Cancer (2017) 17:Page 3 ofRegional lymph nodes cannot be assessed) and distant metastasis (M0; No distant metastasis, and M1; Distant metastasis), SEER stage (localized, regional, and distant), radiation, and pri
Thor(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Quadri et al. BMC Cancer (2017) 17:Page 2 ofBackground While advances in the understanding of cancer biology, s
I:10.1371/journal.pone.0127641. PubMed PMID: 26011708; PMCID: PMC4444265. 40. Li X, Zhang Z, Yu M, Li L, Du G, Xiao W, Yang H. Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2). Int J Mol Sci. 2013;14(8):16226-39. doi:10.3390/ijms140816226. PubMed PMID: 23924943; PMCID: PMC3759908. 41. Yin P, Navarro A, Fang F, Xie A, Coon JS, Richardson C,
Esults in an increased sensitivity to TGF-beta signaling. BMC Cancer. 2011;11:59. PubMed. 31. Imamichi Y, Waidmann O, Hein R, Eleftheriou P, Giehl K, Menke A. TGF betainduced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4. Biol Chem. 2005;386(3):225-236. PubMed. 32. Gauger KJ, Shimono A, Crisi GM, Schneider SS. Loss of SFRP


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